PREDICTOM Level 2 Clinical Study has started
The PREDICTOM is pleased to announce the launch of Level 2 of its international clinical study—an important next step made possible entirely through the generosity, time, and commitment of participants across Europe. The participants' contributions continue to drive forward our shared goal: improving the early detection of Alzheimer’s disease through accessible, reliable, and science-driven tools.
What is included in Level 2 testing?
Level 2 brings participants back to the clinic for a comprehensive series of assessments designed to capture a deeper understanding of biological, cognitive, and neurological markers. Based on the study plan, participants will complete:
Cognitive and functional assessments: Montreal Cognitive Assessment (MoCA), informant-completed ADL questionnaires
Clinical and neurological exams: Medical history review, physical and neurological examinations, vital signs
Bio-sample collection: Venous blood draw, stool/saliva/fingerprick kits, and cerebrospinal fluid collection via lumbar puncture
Neurophysiological and imaging tests: Electroencephalography (EEG), two MRI brain scans or PET scans
Sensory assessments: Eye-tracking and hearing tests
At‑home elements: RUD‑Lite
These assessments are carefully selected to provide a well-rounded view of the early changes associated with Alzheimer's disease.
Photo: colourbox.com
How are participants selected for Level 2?
Participants are invited using research-based criteria such as completeness of initial study data, ensuring diversity across age and demographic factors, and practical considerations. Importantly, an invitation to Level 2 does not indicate anything about a participant’s dementia risk and has no diagnostic significance.
How long does Level 2 take?
Level 2 activities take place across three full study days (in estimation), spread over approximately six weeks. Scheduling is flexible, depending on available resources and time slots, participants will be given opportunities to choose appointment times that fit their availability. A brief follow-up phone call is completed after the lumbar puncture to ensure participant well‑being.
PS: The exact timing for each assessment varies among participants.
– Day 1 (≈4 hours): Cognitive testing, clinical exams, EEG, sensory tests, blood collection, bring-home biofluid kits
– Day 2 (≈2 hours 40 minutes): Return biofluid kits, MRI scans
– Day 3 (≈4 hours): Lumbar puncture and rest period
– Post‑visit: 15‑minute safety phone call
A Shared Effort Toward Better Care
We extend our heartfelt thanks to every participant who has supported PREDICTOM so far. Your involvement brings us closer to a future where Alzheimer’s disease can be identified earlier, treated more effectively, and understood in greater depth. Level 2 is an exciting and meaningful next step—and it would not be possible without you.
