Scientific Publications
2026
Publications
Screening for Alzheimer's disease in the community using an AI-driven screening platform: design of the PREDICTOM study
Anna-Katharine Brem, Zunera Khan, Jonas Radermacher, Kostas Georgiadis, Ioulietta Lazarou & PREDICTOM Consortium.
The Journal of Prevention of Alzheimer's Disease
Recent developments in physiological, imaging and digital biomarkers combined with the approval of new disease-modifying drugs against Alzheimer's disease (AD) and diagnostic blood tests provide an opportunity to shift the first diagnostic steps to the home-setting. While these novel biomarkers enable scalable screening and earlier detection and treatment of AD, they require an evaluation of their accuracy, feasibility, and safety in primary care and the community setting. The aim of PREDICTOM is to develop and test the accuracy of an artificial intelligence (AI) driven screening platform for the risk assessment and early detection of AD to extend the clinical pathway to home-based screening using established and novel biomarkers.
View publication2025
Publications
Exploring Functional Brain Networks in Alzheimer's Disease Using Resting State EEG Signals
Oikonomou, V. P., Georgiadis, K., Lazarou, I., Nikolopoulos, S., Kompatsiaris, I., & PREDICTOM Consortium.
J. Dement. Alzheimer's Dis., 2(2), 12
The study found progressive changes in functional brain connectivity across stages of Alzheimer's disease, marked by increased theta-band betweenness centrality and decreased centrality in the alpha and beta bands. Theta-band betweenness centrality showed the highest discriminative power in identifying disease stages. Connectivity metrics derived from EEG performed on par with advanced deep learning models, highlighting their promise as noninvasive and interpretable biomarkers for early detection and monitoring of Alzheimer's disease.
View publicationINR Meets Multi-contrast MRI Reconstruction
Natascha Niessen, Carolin M. Pirkl, Ana Beatriz Solana, Hannah Eichhorn, Veronika Spieker, Wenqi Huang, Tim Sprenger, Marion I. Menzel & Julia A. Schnabel on behalf of the PREDICTOM consortium
MICCAI Workshop 2025
Multi-contrast MRI sequences allow for the acquisition of images with varying tissue contrast within a single scan. The resulting multi-contrast images can be used to extract quantitative information on tissue microstructure. To make such multi-contrast sequences feasible for clinical routine, the usually very long scan times need to be shortened e.g. through undersampling in k-space. However, this comes with challenges for the reconstruction. In this work, we leverage redundant anatomical information of multi-contrast sequences to achieve even higher acceleration rates.
View publicationAcademic Presentations
A Comparative Study of Magnetic Bead-Based Techniques for Isolating Plasma-Derived Extracellular Vesicles
ISEV2025, 23-27 April 2025, Vienna, Austria
Algorithm using Blood-Based Biomarkers for Alzheimer's Pathology: Scalable Screening in the PREDICTOM Study
DemCon25, 5-6 December, India
Are Resting-State EEG Signals the Key to Decoding Functional Brain Networks in Alzheimer's Disease Spectrum?
AAIC 2025, 12-15 July, Toronto, Canada
Baseline Sociodemographic Characteristics and Risk Factor Profile of Participants Enrolled in the Swiss Cohort of the Predictom Project
Swiss Dementia Forum, November 2025, Geneva
Informed Choices and Early Dementia Risk Disclosure in Home-Based Assessments in the PREDICTOM Study: A Public Involvement Approach
AAIC 2025, 12-15 July, Toronto, Canada
Informed Choices and Early Dementia Risk Disclosure in Home-Based Assessments in the PREDICTOM Study: A Public Involvement Approach
Alzheimer Europe Conference, 6-8 October, Bologna, Italy
INR meets Multi-Contrast MRI Reconstruction
MICCAI Workshop 2025, September 27, Daejeon, South Korea
Machine learning model for early dementia risk prediction using common risk factors in primary care settings
AAIC 2025, 12-15 July, Toronto, Canada
Prediction of Alzheimer's disease using an AI driven screening platform: interim results on feasibility, usability and acceptability of home-based assessments in the PREDICTOM study
AAIC 2025, 12-15 July, Toronto, Canada
PREDICTOM interim results: Evaluating feasibility, usability, and acceptability of home-based AI-supported screening of Alzheimer's disease
Alzheimer Europe Conference, 6-8 October, Bologna, Italy
PREDICTOM launches prospective study, gears up for MR protocol harmonization
GE Healthcare Signa Pulse Journal, Spring 2025
PREDICTOM MR Protocol: Rationales, Design and Initial Validation
OHBM 2025, 23-27 June 2025, Brisbane, Australia
PREDICTOM: Evaluación y validación de una plataforma de cribado de biomarcadores para identificar el riesgo de enfermedad de Alzheimer en el punto de atención sanitaria
Annual Meeting of the Spanish Society of Neurology, 3-5 September, Gran Canaria, Spain
Probing the sparsity of the MPnRAGE sequence through subspace compression
ISMRM 2025, May, Honolulu, Hawaii
Rational and design of PREDICTOM MRI Protocol
AAIC 2025, 12-15 July, Toronto, Canada
Risk stratification for the enrichment of potential high-risk groups in a cognitive normal study population
AAIC 2025, 12-15 July, Toronto, Canada
Zero-Shot Bias Correction: Efficient MR Image Inhomogeneity Reduction without Any Data
ISBI2025, 14-17 April 2025, Houston, Texas
2024
Academic Presentations
Key stakeholder engagement and protocol development for the IHI-funded public-private partnership project PREDICTOM
CTAD 2024, Madrid, Spain
Multifaceted EEG Protocol for Comprehensive Assessment of Alzheimer's Disease Progression during Emotional Processing, Working Memory and Attention Tasks: The PREDICTOM Study
Alzheimer Europe Conference 2024, Geneva
Prediction of Alzheimer's disease using an AI driven screening platform: PREDICTOM study design
AAIC 2024, Philadelphia, USA
Prediction of Alzheimer's disease using an AI driven screening platform: PREDICTOM study design
Alzheimer Europe Conference 2024, Geneva
PREDICTOM Study Protocol
CTAD 2024, Madrid, Spain
Screening for early biofluid markers of Alzheimer's disease in an at-risk population: design of the PREDICTOM study
Neurological Disorders Summit 2024, Barcelona, Spain
Towards AI-based digital biomarkers for early detection of dementia risk using mobile eye tracking
Alzheimer Europe Conference 2024, Geneva